National Instruments Switch NI USB 6221 User Manual
USER GUIDE  
NI USB-6221/6229/6251/6259 OEM  
This document provides dimensions, pinouts, and information  
about the connectors, switch, LEDs, and chassis ground of the  
NI USB-6221/6229/6251/6259 OEM devices.  
Caution There are no product safety, electromagnetic compatibility (EMC), or  
CE marking compliance claims made for the USB-6221/6229/6251/6259 OEM devices.  
Conformity to any and all compliance requirements rests with the end product supplier.  
Figure 1 shows the USB-6221/6251 OEM and USB-6229/6259 OEM  
devices.  
USB-6221/6251  
USB-6229/6259  
Figure 1. USB-6221/6251 and USB-6229/6259 OEM Devices  
Refer to the NI 622x Specifications document for USB-6221/6229  
specifications and the NI 625x Specifications document for  
USB-6251/6259 specifications. Refer to the M Series User Manual for  
more information about USB-6221/6229/6251/6259 devices. You can find  
all documentation at ni.com/manuals.  
 
 
Figure 3 shows the dimensions of the USB-6229/6259 OEM device.  
4X Ø 0.110 (2.79)  
7X Ø 0.125 (3.18)  
6.950 (176.53)  
4x 6.718 (170.63)  
6.270 (159.26)  
6.140 (155.96)  
5.930 (150.62)  
5.839 (148.31)  
5.499 (139.67)  
6.140 (155.96)  
5.760 (146.30)  
5.290 (134.37)  
5.080 (129.03)  
2X Ø 0.156 (3.96)  
2.535 (64.39)  
0.396 (10.06)  
0.304 (7.72)  
0.256 (6.50)  
0.116 (2.95)  
0.000 (0.00)  
0.304 (7.72)  
0.200 (5.08)  
0.436 (11.07)  
0.392 (9.96)  
0.362 (9.19)  
0.162 (4.11)  
0.062 (1.57)  
0.000 (0.00)  
0.515 (13.08)  
2X Ø 0.140 Cutout  
in Panel for LEDs  
Ø 0.330 Cutout in Panel  
for Power Connector  
Figure 3. USB-6229/6259 OEM Dimensions in Inches (Millimeters)  
© National Instruments Corporation  
3
NI USB-6221/6229/6251/6259 OEM User Guide  
 
 
I/O Connector Pinouts  
Figures 4 through 7 show the connector pinouts for the USB-6221 OEM,  
USB-6229 OEM, USB-6251 OEM, and USB-6259 OEM devices.  
Refer to the M Series User Manual at ni.com/manuals for more  
information about USB-6221/6229/6251/6259 signals and how to  
connect them.  
NI USB-6221/6229/6251/6259 OEM User Guide  
4
ni.com  
 
Bank 0  
50-Pin Digital Connector  
+5 V  
50 49 +5 V  
48 47 PFI 15  
46 45 PFI 14  
44 43 PFI 13  
42 41 PFI 12  
40 39 PFI 11  
38 37 PFI 10  
36 35 PFI 9  
34 33 PFI 8  
32 31 PFI 7  
30 29 PFI 6  
28 27 PFI 5  
26 25 PFI 4  
24 23 PFI 3  
22 21 PFI 2  
20 19 PFI 1  
18 17 PFI 0  
16 15 P0.7  
14 13 P0.6  
12 11 P0.5  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
10  
8
9
7
5
3
1
P0.4  
P0.3  
P0.2  
P0.1  
P0.0  
6
4
2
Bank 0  
34-Pin Analog Connector  
AI GND 34 33 AI 15  
AI 7  
32 31 AI GND  
AI 14  
30 29 AI 6  
AI GND 28 27 AI 13  
AI 5  
26 25 AI GND  
AI 12  
24 23 AI 4  
AI GND 22 21 AI 11  
AI 3  
20 19 AI GND  
AI 10  
18 17 AI 2  
AI GND 16 15 AI 9  
AI 1  
14 13 AI GND  
AI 8  
12 11 AI 0  
AI GND 10  
9
7
5
3
1
AI SENSE  
NC  
AI GND  
AI GND  
AO 1  
8
6
4
2
AO GND  
AO GND  
AO GND  
AO 0  
NC = No Connect  
Figure 4. USB-6221 OEM Connector Pinout  
© National Instruments Corporation  
5
NI USB-6221/6229/6251/6259 OEM User Guide  
 
 
Bank 1  
Bank 0  
50-Pin Digital Connectors  
+5 V  
50 49 +5 V  
48 47 P0.31  
46 45 P0.30  
44 43 P0.29  
42 41 P0.28  
40 39 P0.27  
38 37 P0.26  
36 35 P0.25  
34 33 P0.24  
32 31 P0.23  
30 29 P0.22  
28 27 P0.21  
26 25 P0.20  
24 23 P0.19  
22 21 P0.18  
20 19 P0.17  
18 17 P0.16  
16 15 P0.15  
14 13 P0.14  
12 11 P0.13  
+5 V  
50 49 +5 V  
48 47 PFI 15  
46 45 PFI 14  
44 43 PFI 13  
42 41 PFI 12  
40 39 PFI 11  
38 37 PFI 10  
36 35 PFI 9  
34 33 PFI 8  
32 31 PFI 7  
30 29 PFI 6  
28 27 PFI 5  
26 25 PFI 4  
24 23 PFI 3  
22 21 PFI 2  
20 19 PFI 1  
18 17 PFI 0  
16 15 P0.7  
14 13 P0.6  
12 11 P0.5  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
10  
8
9
7
5
3
1
P0.12  
P0.11  
P0.10  
P0.9  
10  
8
9
7
5
3
1
P0.4  
P0.3  
P0.2  
P0.1  
P0.0  
6
6
4
4
2
P0.8  
2
Bank 1  
Bank 0  
34-Pin Analog Connectors  
AI GND 34 33 AI 31  
AI GND 34 33 AI 15  
AI 23  
32 31 AI GND  
AI 7  
32 31 AI GND  
AI 30  
30 29 AI 22  
AI 14  
30 29 AI 6  
AI GND 28 27 AI 29  
AI GND 28 27 AI 13  
AI 21  
26 25 AI GND  
AI 5  
26 25 AI GND  
AI 28  
24 23 AI 20  
AI 12  
24 23 AI 4  
AI GND 22 21 AI 27  
AI GND 22 21 AI 11  
AI 19  
AI 26  
20 19 AI GND  
AI 3  
20 19 AI GND  
18 17 AI 18  
AI 10  
18 17 AI 2  
AI GND 16 15 AI 25  
AI GND 16 15 AI 9  
AI 17  
AI 24  
14 13 AI GND  
AI 1  
14 13 AI GND  
12 11 AI 16  
AI 8  
12 11 AI 0  
AI GND 10  
9
7
5
3
1
AI SENSE 2  
NC  
AI GND 10  
9
7
5
3
1
AI SENSE  
NC  
AI GND  
AI GND  
AO 3  
8
6
4
2
AI GND  
AI GND  
AO 1  
8
6
4
2
AO GND  
AO GND  
AO GND  
AO GND  
AO GND  
AO GND  
AO 2  
AO 0  
NC = No Connect  
NC = No Connect  
Figure 5. USB-6229 OEM Connector Pinout  
NI USB-6221/6229/6251/6259 OEM User Guide  
6
ni.com  
 
Bank 0  
50-Pin Digital Connector  
+5 V  
50 49 +5 V  
48 47 PFI 15  
46 45 PFI 14  
44 43 PFI 13  
42 41 PFI 12  
40 39 PFI 11  
38 37 PFI 10  
36 35 PFI 9  
34 33 PFI 8  
32 31 PFI 7  
30 29 PFI 6  
28 27 PFI 5  
26 25 PFI 4  
24 23 PFI 3  
22 21 PFI 2  
20 19 PFI 1  
18 17 PFI 0  
16 15 P0.7  
14 13 P0.6  
12 11 P0.5  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
10  
8
9
7
5
3
1
P0.4  
P0.3  
P0.2  
P0.1  
P0.0  
6
4
2
Bank 0  
34-Pin Analog Connector  
AI GND 34 33 AI 15  
AI 7  
32 31 AI GND  
AI 14  
30 29 AI 6  
AI GND 28 27 AI 13  
AI 5  
26 25 AI GND  
AI 12  
24 23 AI 4  
AI GND 22 21 AI 11  
AI 3  
20 19 AI GND  
AI 10  
18 17 AI 2  
AI GND 16 15 AI 9  
AI 1  
14 13 AI GND  
AI 8  
12 11 AI 0  
AI GND 10  
9
7
5
3
1
AI SENSE  
APFI 0  
AI GND  
AI GND  
AO 1  
8
6
4
2
AO GND  
AO GND  
AO GND  
AO 0  
Figure 6. USB-6251 OEM Connector Pinout  
© National Instruments Corporation  
7
NI USB-6221/6229/6251/6259 OEM User Guide  
 
Bank 1  
Bank 0  
50-Pin Digital Connectors  
+5 V  
50 49 +5 V  
48 47 P0.31  
46 45 P0.30  
44 43 P0.29  
42 41 P0.28  
40 39 P0.27  
38 37 P0.26  
36 35 P0.25  
34 33 P0.24  
32 31 P0.23  
30 29 P0.22  
28 27 P0.21  
26 25 P0.20  
24 23 P0.19  
22 21 P0.18  
20 19 P0.17  
18 17 P0.16  
16 15 P0.15  
14 13 P0.14  
12 11 P0.13  
+5 V  
50 49 +5 V  
48 47 PFI 15  
46 45 PFI 14  
44 43 PFI 13  
42 41 PFI 12  
40 39 PFI 11  
38 37 PFI 10  
36 35 PFI 9  
34 33 PFI 8  
32 31 PFI 7  
30 29 PFI 6  
28 27 PFI 5  
26 25 PFI 4  
24 23 PFI 3  
22 21 PFI 2  
20 19 PFI 1  
18 17 PFI 0  
16 15 P0.7  
14 13 P0.6  
12 11 P0.5  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
D GND  
10  
8
9
7
5
3
1
P0.12  
P0.11  
P0.10  
P0.9  
10  
8
9
7
5
3
1
P0.4  
P0.3  
P0.2  
P0.1  
P0.0  
6
6
4
4
2
P0.8  
2
Bank 1  
Bank 0  
34-Pin Analog Connectors  
AI GND 34 33 AI 31  
AI GND 34 33 AI 15  
AI 23  
32 31 AI GND  
AI 7  
32 31 AI GND  
AI 30  
30 29 AI 22  
AI 14  
30 29 AI 6  
AI GND 28 27 AI 29  
AI GND 28 27 AI 13  
AI 21  
26 25 AI GND  
AI 5  
26 25 AI GND  
AI 28  
24 23 AI 20  
AI 12  
24 23 AI 4  
AI GND 22 21 AI 27  
AI GND 22 21 AI 11  
AI 19  
AI 26  
20 19 AI GND  
AI 3  
20 19 AI GND  
18 17 AI 18  
AI 10  
18 17 AI 2  
AI GND 16 15 AI 25  
AI GND 16 15 AI 9  
AI 17  
AI 24  
14 13 AI GND  
AI 1  
14 13 AI GND  
12 11 AI 16  
AI 8  
12 11 AI 0  
AI GND 10  
9
7
5
3
1
AI SENSE 2  
APFI 1  
AI GND 10  
9
7
5
3
1
AI SENSE  
APFI 0  
AI GND  
AI GND  
AO 3  
8
6
4
2
AI GND  
AI GND  
AO 1  
8
6
4
2
AO GND  
AO GND  
AO GND  
AO GND  
AO GND  
AO GND  
AO 2  
AO 0  
Figure 7. USB-6259 OEM Connector Pinout  
NI USB-6221/6229/6251/6259 OEM User Guide  
8
ni.com  
 
 
LEDs  
USB-6221/6229/6251/6259 OEM devices have two LEDs that reflect  
the device state. The green READY LED indicates whether the device is  
powered on and configured as a USB device. The yellow ACTIVE LED  
indicates whether there is USB bus activity.  
Three connectors on the device allow you to connect an external LED  
circuit to the device. To connect an external READY LED, use E1 as the  
positive connection (+3.3 V) and E2 as the negative connection. To connect  
an external ACTIVE LED, use E1 as the positive connection and E3 as the  
negative connection. E1 is current limited with a 100 Ω resistor to the 3.3 V  
internal supply. This configuration limits the current to approximately  
16 mA into a single external LED or approximately 8 mA each when both  
LEDs are on. You also can limit this current further by using external  
resistors as shown in Figure 8.  
DS1  
E3  
E2  
E1  
Figure 8. USB-6221/6229/6251/6259 OEM LEDs  
Figure 9 shows how to connect an external READY or ACTIVE LED  
circuit to the device.  
Internal  
3.3 V  
100 Ω  
External  
READY LED  
External  
ACTIVE LED  
E1  
External Resistor  
External Resistor  
E2  
E3  
Figure 9. Schematics of the USB-6221/6229/6251/6259 OEM LEDs  
© National Instruments Corporation  
9
NI USB-6221/6229/6251/6259 OEM User Guide  
 
   
Power Switch  
The power switch on the USB-6221/6229/6251/6259 OEM device powers  
the device on and off. Figure 10 shows the pins on the power switch.  
Provides  
Power to  
VDC Comes  
from Fuse  
Device  
2
3
1
J4  
SW1  
100 kΩ  
Switch  
4
5
Outer  
Shell  
Figure 10. Power Switch (USB-6229/6259 OEM Shown)  
Pin 1 is connected to VDC through the fuse (reference designator XF1).  
The VDC is the voltage provided by the power supply through the power  
connector (reference designator J4) and must be 11–30 V, 20 W.  
Pin 2 provides power to the circuitry on the USB-6221/6229/6251/6259  
OEM device. When the switch is in the On position, the VDC power supply  
from pin 1 is routed to pin 2.  
Pin 3 connects pin 2 to ground through a 100 kΩ resistor when the switch  
is in the Off position. This allows the internal power supply in the  
USB-6221/6229/6251/6259 OEM device to safely discharge to ground  
when it is powered off. Figure 11 shows a schematic of the switch.  
XF1  
J4  
SW1  
1
2
Power to  
Device  
Power  
Connector  
FUSE  
3
100 kΩ  
Figure 11. Schematic of the USB-6221/6229/6251/6259 OEM Switch  
NI USB-6221/6229/6251/6259 OEM User Guide  
10  
ni.com  
 
   
Chassis Ground  
Chassis ground provides a connection between the enclosure and USB  
ground.  
D GND is connected to the chassis ground through an internal connection  
to hole A, shown in Figure 12. The chassis ground directly connects to USB  
shield ground.  
The USB-6221/6229/6251/6259 OEM device includes several mounting  
holes that are plated and designed for user-configured ground connections  
between the device chassis ground and the appropriate system ground.  
Figure 12 shows where the different grounds are connected.  
Note The holes that are labeled B are reserved for an external shield. Do not use these  
holes as mounting holes.  
B
B
B
A
Mounting Hole Connected  
to Chassis Ground  
Figure 12. Ground Connections (USB-6229/6259 OEM Shown)  
© National Instruments Corporation  
11  
NI USB-6221/6229/6251/6259 OEM User Guide  
 
 
Device Components  
Table 1 contains information about the components used for interfacing  
and interacting with the USB-6221/6229/6251/6259 OEM device.  
Table 1. USB-6221/6229/6251/6259 OEM Components  
Reference  
Designator(s)  
on PCB  
Manufacturer  
Part Number  
Component  
Manufacturer  
Dialight  
LEDs  
DS1  
J1, J2*  
P1, P2*  
J3  
553-0332  
34-pin connectors  
50-pin connectors  
USB connector  
3M  
N2534-6002RB  
N2550-6002UB  
787780-1  
3M  
AMP  
Power connector  
Power switch  
J4  
Switchcraft  
ITT Industries, Cannon  
Littelfuse  
722RA  
SW1  
XF1  
J6*, J7  
E101J1A3QE2  
217.002  
F 2A L 250V fuse  
68-pin connectors†  
Honda  
PCS-E68RLMD1+  
* J2, P2, and J6 are available on USB-6229/6259 OEM devices only.  
† Optional mass termination connectors. These are not populated by default.  
National Instruments, NI, ni.com, and LabVIEW are trademarks of National Instruments Corporation.  
Refer to the Terms of Use section on ni.com/legal for more information about National  
Instruments trademarks. Other product and company names mentioned herein are trademarks or trade  
names of their respective companies. For patents covering National Instruments products, refer to the  
appropriate location: Help»Patents in your software, the patents.txt file on your CD, or  
ni.com/patents.  
© 2006 National Instruments Corporation. All rights reserved.  
371910B-01  
Oct06  
 
 

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